Regional integration in Asia and the Pacific is progressing steadily. Regional integration, as measured by the Asia-Pacific Regional Cooperation and Integration Index, has progressed steadily over the past 15 years and remained stable in 2020 despite the pandemic. The Asia-Pacific Regional Cooperation and Integration Index subindexes such as trade and investment, infrastructure, and digital connectivity have been notably buoyant. Southeast Asia fares better than other subregions in the dimensions of trade and investment, money and finance, infrastructure and connectivity, institutional arrangements, and people and social dynamics. Looking ahead, it is critical to deepen regional cooperation to address pressing climate challenges and advance trade and supply chain resilience, the digital economy, and sustainable tourism recovery. With Asia’s growing role in the fight against climate change, regional cooperation is vital for decarbonizing its production, and trade and investment.