This report describes the development of key factors in framework design for the Health System–Community Pathways Program (HCPP), which aims to increase representation of African American/Black communities in the health care system workforce. Called the HCPP framework of key factors, it is informed by an environmental scan, interviews, focus groups, and an expert discussion panel session. The ultimate goal of the HCPP framework of key factors is to increase both the number of African American/Black individuals successfully pursuing careers in health care and the quality of their educational and work experiences. The report’s authors come from diverse backgrounds; the team included African American/Black physicians and members of other historically marginalized communities. Moreover, the qualitative research that serves as the foundation for the HCPP framework of key factors drew insights from a diverse set of African American/Black community stakeholders, including health care providers, youth educators, local leaders of community and grassroots community organizations, parents, and activists. Finally, the report itself was reviewed by many of the stakeholders. All of these efforts were meant to ensure that the design of the research and the end product resonate with and maximally benefit the community on which they focus.