At the 1996 World Food Summit, the Heads of State and Government reaffirmed the right of everyone to have access to safe and nutritious food, consistent with the right to adequate food and the fundamental right of everyone to be free from hunger (World Food Summit, 1996). To achieve this commitment, agrifood systems will need to be transformed to sustainably deliver safe and nutritious food for all. The Food and Agriculture Organization of the United Nations’ (FAO) Strategic Framework focuses on this transformation through achieving four pillars: better production, better nutrition, a better environment, and a better life (FAO, 2021). To “realize our shared vision for a better world” (UN Food Systems Summit, 2021) and to be better prepared to mitigate potential shocks and disruptions, we need to develop and maintain a deep understanding of the future opportunities, challenges and threats to our agrifood systems. The FAO food safety foresight programme is geared towards the proactive identification, evaluation and prioritization of emerging trends and drivers within and around agrifood systems that can have food safety implications (Figure 1). This will lead to improved and timely strategic planning to better manage potential risks and be ready to take advantage of new opportunities.