Enterprise stakeholders must consider the challenges of increased real-time system complexity, the need for new cybersecurity policy, and the strong cultural support that is required to securely operate systems in a complex and hybrid world. Emerging technology solutions and approaches such as Zero Trust are critical to meeting the mandates in United States President Biden’s Executive Order 14028, Improving the Nation’s Cybersecurity. The implications of an emerging, rich, and diverse solutions landscape and the challenges to an organization’s ability to ultimately deliver a Zero Trust architecture (ZTA) are explored in this paper. Recommendations are discussed for how industry can improve collaboration among key stakeholder groups to accelerate both enterprise leaders’ and security practitioners’ adoption of Zero Trust into their environments.