Drug shortages are a persistent public health problem in the United States and in othercountries. Shortages can have important implications for the health care systems and pharmaciesthat purchase, store, and dispense drugs and for the patients who rely on the availability of drugsto treat and prevent disease. Although prior analyses explore the frequency of drug shortages inthe United States, little is known about the extent to which U.S. drug shortages are associatedwith shortages in other countries. This report describes the characteristics of drugs for whichthere have been recent shortages in the United States. These drugs were identified using twosources: the U.S. Food and Drug Administration’s Center for Drug Evaluation and Research andthe American Society of Health-System Pharmacists. We describe changes in U.S. volume,price, and other metrics through the start of U.S. shortages and assess whether U.S. shortages areassociated with changes in volume, price, and other outcomes in other countries.