Year after year, slow and unpredictable investigator payments continue to be a top complaint from clinical study sites. For this reason, Bayer initiated a project called Automated Site Payment Invoice Resolution (ASPIREs), through which Bayer realized two ambitious goals of optimizing the clinical trial site payment process and enabling site management teams to focus more on value-added activities. The project kicked off in 2019 with a pilot in the United States, followed by a roll out in six additional countries. As of today, Bayer has rolled out ASPIREs into 18 countries across the globe.