A persistent pandemic and global geopolitical conflict continue to dominate headlines. Sustainability concerns are escalating, and extreme weather conditions are more frequent. And with inflation expected to reach historic highs, this generation of business leaders is facing yet another extraordinary situation. Navigating uncertainties—and managing supply chain challenges accordingly—has out of necessity become a top business priority for boards and C-suites alike. Over the next two to three years, Chief Supply Chain Officers (CSCOs) say that issues related to supply chain disruptions, technology infrastructure, sustainability, and market shifts are their greatest challenges. Yet when addressed with an open mindset, challenges create opportunities within the enterprise—and visibility. A heightened emphasis on supply chain functionalities and roles is giving CSCOs the expertise, latitude, and organizational authority to innovate into a data-led future.