This manual describes the implementation of the Collaboration Leading to Addiction Treatment and Recovery from Other Stresses (CLARO) intervention, as part of a clinical trial that adapted the Collaborative Care Model for adults with opioid use disorder co-occurring with depression and/or posttraumatic stress disorder. Implementation took place at 19 primary care clinic sites in New Mexico and California: First Choice Community Healthcare (eight clinics), Hidalgo Medical Services (three clinics), the University of New Mexico (UNM) (three clinics), and the Los Angeles County Department of Health Services (five clinics). The purpose of this manual is to describe the strategies and team roles used to support successful implementation of the CLARO intervention. It serves as a companion to CLARO Intervention User Manual: A Guide for Care Teams and Individual Practitioners (Osilla, Hurley, et al., 2023), which describes the day-to-day clinical roles and responsibilities of the Collaborative Care Team for delivering the intervention. The Intervention User Manual is meant for use by clinical teams when delivering the CLARO intervention to patients, whereas this Implementation Manual is meant for use by implementation teams and other decisionmakers to support clinical teams’ adoption and use of the CLARO intervention in a clinic(s) or health system(s).