Defining characteristics of cell and gene therapy (CAGT) clinical trial operations include complex protocols, the need to manage expensive and often irreplaceable assets, and accelerated timelines. These features demand that clinical operations teams ensure meticulous planning, oversight, and training around supply chain logistics. The interdependency of the manufacturing process, shipping, site handling of the asset, and the patient journey require a holistic logistics management strategy that takes into account all these factors from the beginning and addresses needs beyond simply tracking assets. A holistic approach to logistics management is also key to supporting sites, because it allows for better risk management and compliance.