Outbreaks of vaccine preventable diseases have continued to affect many parts of the United States. Measles particularly made a striking comeback in 2019, resulting in the greatest number of cases ever seen since it was declared eliminated two decades ago. The majority of the cases were among the under-or un-vaccinated, and whose vaccination status was mostly due to parents’ or own personal beliefs. While the causes of the growing vaccine hesitancy are likely to be multifactorial, the prevalence of misinformation on social media arguably plays a crucial role. To combat vaccine misinformation in today’s digital world, policymakers and other stakeholders need a more complete picture of the production, dissemination, and consumption of misinformation on social media.