The COVID-19 crisis has not only revealed a world that has moved into an age of interdependence and competition,it has also laid bare Europe’s strategic loneliness and vulnerability. The pandemic has degraded the perception of the role played by the main world powers, especially the United States and China. The main challenge for Europe will be to review its place in the world and its interactions with the main powers, starting with the United States. Despite an improvement in tone of the transatlantic relationship under a Biden administration, the next US president will have to give priority to domestic issues and look for reliable partners. The European Union has no other option than to present itself as a capable and credible player. Its capacity to assert itself as a pole of stability by defusing tensions in its neighbourhood and improving regional security will be the ultimate test regarding its ambition to become a geopolitical power.